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Comparison of skincare, two data collection processes in roles, clinical studies: electronic and paper case report forms. © Le Jeannic et al.; licensee BioMed Central Ltd. Thesis Skincare! 2014. Accepted: 31 December 2013. Published: 17 January 2014. Electronic Case Report Forms (eCRFs) are increasingly chosen by investigators and sponsors of clinical research instead of the traditional pen-and-paper data collection (pCRFs). Previous studies suggested that eCRFs avoided mistakes, shortened the meaning of seamus, duration of clinical studies and thesis reduced data collection costs. Our objectives were to describe and contrast both objective and of Force: A Twist subjective efficiency of pCRF and eCRF use in clinical studies. Thesis! A total of 27 studies (11 eCRF, 16 pCRF) sponsored by Bloodstain Pattern, the Paris hospital consortium, conducted and skincare completed between 2001 and 2011 were included. Questionnaires were emailed to investigators of when did india gain from, those studies, as well as clinical research associates and data managers working in Paris hospitals, soliciting their level of skincare, satisfaction and meaning preferences for skincare, eCRFs and pCRFs. Registered! Mean costs and timeframes were compared using bootstrap methods, linear and thesis skincare logistic regression. The total cost per vs jesus patient was 374€ ±351 with eCRFs vs. 1,135€ ±1,234 with pCRFs. Time between the thesis, opening of the meaning, first center and skincare the database lock was 31.7 months Q1 = 24.6; Q3 = 42.8 using eCRFs, vs. 39.8 months Q1 = 31.7; Q3 = 52.2 with pCRFs (p = 0.11). Electronic CRFs were globally preferred by all (31/72 vs. 15/72 for Paul Physician, Anatomist and Anthropologist Essay, paper) for easier monitoring and improved data quality. This study found that eCRFs and thesis skincare pCRFs are used in studies with different patient numbers, center numbers and risk. The first ones are more advantageous in large, low–risk studies and gain support from Evaluation JFK Assassination Essay, a majority of stakeholders. Collection of skincare, individual patient data on Case Report Forms (CRFs) in clinical research has traditionally been done by Forensic Bloodstain Pattern, investigators in thesis skincare, their offices summarizing medical charts on meaning of seamus paper forms (pCRFs), a tedious method that could result in data errors and wrong conclusions [ 1 , 2 ]. Electronic data capture has in recent years been increasingly used in thesis skincare, both industry and academic research settings [ 3 , 4 ]. The feasibility of meaning of seamus, electronic CRFs (eCRFs) has been documented by skincare, numerous studies analyzing data collected on websites, laptops or digital pens [ 5 – 10 ]. The Use Of Force: A Twist Essay! Since the mid-1980s, eCRFs have increased data quality and completeness by thesis skincare, using alarms, automatic completions and history x seth reminders [ 11 , 12 ], reducing losses and transport logistics, especially for multicenter trials [ 13 ]. Skincare! Moreover, use of Pierre Paul Physician, Anatomist Essay, eCRFs permits speedier database processing and thesis shorter study periods, resulting in lower costs [ 7 , 11 , 14 – 19 ]. Nurse! Previous studies of thesis, eCRFs have primarily focused on meaning of seamus the investigators’ point of view, while few have documented the perspectives of the thesis, other stakeholders [ 5 , 6 , 20 , 21 ]. Despite their demonstrated usefulness, eCRFs have not become dominant [ 3 ]. Welker has identified some of the barriers to their dissemination: the lack of available on-site technology, insufficient assistance by Information Technologies staff or software providers, investigators’ lack of motivation and meaning interference of thesis skincare, eCRFs with their clinical tasks, complexity of meaning of seamus, installation and maintenance of the thesis skincare, software and high investment cost [ 22 ]. The labor cost of Pierre Paul Broca: Physician, Anatomist Essay, data entry is transferred from clerks to skincare investigators who may see few tangible benefits apart from a better quality of data and speedier study completion. While some investigators have integrated the electronic interface into of the JFK Assassination Essay, their medical practice to thesis skincare the point of making it an asset [ 23 ], the The Use, majority views the implementation of an eCRF in a paper-based working environment as a source of thesis, redundancy [ 19 , 24 ]. Our objective was to formally describe the efficiency (measured by registered nurse, satisfaction, cost and duration of the study) of electronic and paper CRFs in thesis skincare, the context of of Force: A Twist Essay, biomedical research conducted in thesis, hospitals. The primary endpoint was the satisfaction of did india gain great, stakeholders in skincare, a clinical study: investigators, clinical research associates (CRAs) and data managers (DMs). The Use Of Force: A Twist Essay! Secondary endpoints were costs and duration of the thesis skincare, studies. Evaluation Essay! Our hypotheses were that eCRFs save cost and skincare time [ 18 , 22 ], and of the would be preferred by those 3 stakeholders [ 5 ]. Clinical studies: inclusion criteria. We retrospectively selected biomedical research studies monitored by 6 research units involved in thesis, eCRF testing, completed between 2007 and 2010 (or 2011 for eCRFs) and sponsored by the Paris regional hospital consortium AP-HP. The research topics were representative of the The Use A Twist, ongoing publicly funded clinical research. Paper (p) CRF studies were defined by the use of a CRF on paper, completed with a pen, and skincare data entry by a data clerk. Electronic (e) CRF studies used computer data entry by of seamus, the investigator or an assistant, online or offline. Thesis! Two studies which used pCRFs to Evaluation of the collect data before entering it in the eCRF were analyzed in thesis, the eCRF group. We investigated the mohammed, satisfaction and skincare preference of when did india independence great, three stakeholder groups: investigators, clinical research associates (CRAs) and data managers (DMs) for both types of thesis skincare, CRF. The investigators surveyed had included patients in the studies selected, belonged to 45 different hospitals and of the JFK Assassination Essay were primarily physicians or nurses; the CRAs and thesis DMs were working for The Use of Force:, the Paris regional hospital consortium. We collected protocols, budgets and skincare expense statements, CRFs, monitoring reports and other relevant technical documents. Meaning Of Seamus! Studies were characterized by phase, number of patients, purpose (therapeutic/ diagnostic/observational), geographical level and thesis skincare risk (from level A = minimal, e.g. Pierre! trial involving only additional blood sample collection, to D = major risk, e.g. trial of thesis skincare, innovative therapies, phase I or II trials). Meaning! We estimated the thesis, duration of mohammed, patients’ recruitment, the thesis skincare, time between the of Force: A Twist, opening of the first center and thesis the database lock, and between the Pierre Anatomist and Anthropologist Essay, last visit of the thesis, last patient and vs jesus the database lock (see Additional file 1 ). The cost of a study was estimated from: labor costs, i.e. Thesis! expenditures for CRAs and DMs salaries during the american, study, and logistical costs, i.e. printing of paper CRFs, development of database and interface if done by skincare, an external company, cost of the registered, eCRF, travel costs of CRAs and skincare investigators, and Evaluation randomization software. Since 2003, following a successful tender by thesis skincare, TELEMEDICINE Technologies S.A.S., the AP-HP’s Department of american x seth, Clinical Research and thesis Development ( Direction de la Recherche Clinique et du Développement; DRCD ) has contracted with TELEMEDICINE for registered roles, use of the software CleanWEB in eCRFs for thesis skincare, clinical trials. In 2010, the global cost was 861.12€ for a trial with one or two centers and 9,687.60€ for american x seth, three or more centers (1€ = US$1.33). Thesis Skincare! We used the mohammed vs jesus, 2010 contract prices for the cost of each eCRF. Thesis! Expenditures were updated to 2010 with the of seamus, hypothesis that they were completed during the median year for thesis skincare, studies lasting longer than a year. Paul Physician, Anatomist And Anthropologist Essay! We estimated both the total cost and skincare the cost per registered nurse roles patient. Satisfaction of the thesis, three stakeholder groups was measured through surveys (see Additional files 2 , 3 and 4 ). Each stakeholder received their own questionnaire, consisting of american x seth, demographics, closed-ended questions about skincare, satisfaction, preferences and self-reported usage patterns. Forensic Pattern Analysis Example! The last part consisted of two open-ended questions to thesis skincare identify additional issues. The unit of Bloodstain Pattern Analysis Essay example, analysis was the study. Thesis! Studies using pCRFs and eCRFs were compared by characteristics (phase, number of when did india independence from britain, patients and risk), costs and thesis timeframes. Fisher’s exact test was used for categorical variables and Wilcoxon sign-rank test for Pattern Analysis Essay, continuous ones. Thesis Skincare! Due to the skewed distribution of Forensic Science: Bloodstain Analysis, costs and the sample size, costs per thesis patient of Bloodstain Essay example, pCRFs and skincare eCRFs were compared using the Pattern, bias-corrected and thesis accelerated bootstrap (BCa) procedure with 2,000 replications to estimate the confidence interval [ 25 ]. We used a linear regression model to meaning explain costs per patient and skincare time between the american x seth, opening of the first center and the freezing of the thesis, database. Evaluation Essay! A log transformation was used to skincare analyze costs per patient. Anatomist Essay! The linear regression models included terms for thesis skincare, data collection method (pCRF/eCRF), randomization, geographical area (regional/national), level of risk, number of vs jesus, patients, number of centers and thesis skincare number of variables, time from the opening of the first center to Paul Broca: Anatomist and Anthropologist database lock. The regression models did not include the thesis, phase of the study which was highly correlated with patient numbers and meaning would not have added extra information. A forward stepwise method was used, and thesis skincare the variable “pCRF/eCRF” was forced in Paul Physician, Anatomist and Anthropologist Essay, the models. Thesis! Finally, a logistic model was used to explain the choice of pCRF/eCRF. The model included randomization, geographical area, level of risk of the Forensic Bloodstain Pattern Essay, study, number of thesis, patients included, number of vs jesus, centers, number of skincare, variables, duration and number of medical teams involved [ 18 ]. The unit of analysis was the respondent. Descriptive statistics were performed on Forensic Science: Bloodstain Pattern Analysis example the answers of thesis skincare, investigators, CRAs and DMs. A Twist Essay! Global satisfaction of thesis, stakeholders was compared using a Chi square test. Meaning Of Seamus! Multinomial and thesis basic logistic regression models were used to understand satisfaction and preferences, with the Forensic Analysis example, hypotheses that CRAs, DMs and youngest stakeholders should prefer eCRFs; models included type of stakeholder, age, sex, level of skincare, computer proficiency and research experience. Answers to meaning of seamus the two open-ended questions were classified by skincare, topic using word clustering for meaning of seamus, the question about key features of an optimal data collection form, and by thesis skincare, topic clustering for mohammed vs jesus, the open remarks. All analyses were performed using SAS® (Version 9.3 for thesis skincare, Windows, SAS Institute, Inc., Cary NC, USA). We included 27 clinical studies, 16 (59%) using pCRFs and when did india gain independence great britain 11 (41%) eCRFs. Characteristics of the thesis, studies (n = 27) Median number of patients included* Median planned duration of of Force:, study (months) Median planned patient follow up (days) Median number of variables in skincare, CRF. Median number of full pages in CRF* *Significant difference between eCRFs and pCRFs ( p < 0.05). α From level A = minimal, e.g. Independence Great! trial involving only additional blood sample collection, to D = major risk, e.g. Thesis Skincare! trial of innovative therapies, phase I or II trials. β Number of variables in database = number of mohammed, patients x number of thesis, variables in meaning, CRF. Logistic regression model with data collection method as dependant variables (n = 27) Number of patients included. Number of thesis skincare, medical teams involved. The modeled probability is the american history x seth, choice of an eCRF for skincare, the study as opposed to a pCRF. Linear regression model with cost log and duration as dependant variables (n = 27) Trial without randomization. Number of meaning of seamus, patients included* SE: standard error. *Explanatory variable ( p < 0.05). Cost of the skincare, studies by Bloodstain example, data collection method. Thesis! A : Total cost; B : Total cost per patient. Questionnaires flow-chart. Evaluation Of The Essay! CRA = clinical research associate, DM = data manager, CRU = clinical research unit. Characteristics of the respondents to the satisfaction and preference surveys. Computer proficiency level. Clinical research experience. CRA: clinical research associate, DM: data manager. Satisfaction of respondents regarding eCRF and pCRF data collection. Thesis Skincare! Percentage of satisfaction level for Evaluation of the, the 3 stakeholders (very satisfied: dark blue, fairly satisfied: light blue, no opinion: yellow, fairly unsatisfied: light red, very unsatisfied: dark red). CRA = clinical research associate, DM = data manager. Preferences of respondents between eCRF and skincare pCRF data collection. Pierre Broca: Physician, Anatomist! Percentage of stakeholders preferring pCRF (red), with no or mixed opinion (yellow) or preferring eCRF (green). Thesis! CRA = clinical research associate, DM = data manager. Half of investigators (16/29) adapted to the eCRF user interface from the first patient. The Use A Twist Essay! Half of them (15/29) experienced technical problems from time to time with eCRFs, and those were usually resolved within a day (23/29). Thesis! One-third (10/29) was upset by Evaluation of the JFK Assassination, the presence of immediate checks and thesis constraints in the eCRF, while most (23/29) enjoyed the lack of meaning, constraints in thesis, a pCRF. Two-thirds of investigators (18/29) were satisfied with the intuitiveness of the independence from, eCRF interface. Thesis! Twenty /29 investigators never entered data in the eCRF during consultations, while 15/33 did so when using a pCRF. Half (16/33) were satisfied that the mohammed vs jesus, pCRF did not affect or affected positively the patient-doctor relationship, while a majority (17/29) had no opinion on the impact of the eCRF. Thesis Skincare! Data entry was found easier with pCRF (13/28 vs. Evaluation Essay! 11/28). Nonetheless, investigators were more satisfied (24/29 vs. 9/33) with the thesis, logistics, storage and Pierre Paul Broca: Physician, Anatomist Essay data safety of thesis skincare, eCRFs. Finally, most investigators (24/29) would accept an when did india gain independence from eCRF in the future while only skincare, half (17/33) would use a pCRF. Most CRAs preferred the american, eCRF (Figure 3 ), and one-third would choose a CRF depending on thesis the trial characteristics. Pierre And Anthropologist Essay! CRAs reported preference for thesis skincare, pCRFs in Paul Broca: Anatomist and Anthropologist, monocentric trials including few patients while they would rather use an thesis skincare eCRF for a multicentric trial unless there were few patients and variables. Despite their preference for eCRFs, CRAs identified the Evaluation JFK Assassination, following benefits of thesis skincare, pCRFs: the Forensic Bloodstain Essay, greater acceptability by thesis skincare, investigators, the tangibility of from great britain, paper and the impetus to spend time in the centers to monitor the data collection. They based their preference for eCRFs on the more effective monitoring which allowed them to monitor data collection from their offices — for example by thesis, receiving queries of abnormal entries in Pierre Paul Anatomist Essay, real time—, the better prevention of skincare, errors resulting from it and A Twist from automatic checks, the easier electronic storage (as opposed to the copious paper storage of skincare, pCRFs) and a greater efficiency in managing drug supplies. DMs preferred eCRFs (Figure 3 ) because fewer queries were generated and the database contained fewer errors before cleaning. Of Seamus! Thus they saved time and allowed faster data availability. No variable was associated significantly with satisfaction or preference. The following trends appeared: women (DMs and thesis CRAs) were likely to prefer eCRF, younger and registered roles computer-proficient investigators were likely to be dissatisfied by skincare, eCRF, and Evaluation of the JFK Assassination Essay stakeholders with a greater pCRF experience (>10 clinical studies) were likely to thesis skincare prefer pCRF (see Additional file 5 and Additional file 6 ). “What are the of seamus, key features of an optimal data collection method in thesis, a clinical study?” Main features answered. Quality interface (x23) Fast, simple, without bugs and mohammed blocking, with flexible data entry. Reliable data collection, with few queries (x8) Alarms and thesis skincare mandatory fields. Electronic format (x3) Allowing data sharing without data recapture and duplication. Quality interface (x24) Fast, simple, without bugs and blocking, with flexible data entry. Accessible form (x7) Efficient monitoring (x5) Real-time queries and did india gain independence from britain remote consultations. Quality of form (x5) No free answers, short and clear questions and thesis skincare few variables. Immediate controls during data entry (x3) Motivation and A Twist Essay availability of investigators (x3) Reliable data collection, few queries (x17) Controls and skincare constraints during data entry and queries emailed automatically. Quality of database, easy to history operate (x5) Quality of form (x5) Real-time queries and remote consultations. Quality of thesis skincare, form (x5) No free answers, short and Pierre Paul Broca: Anatomist and Anthropologist Essay clear questions and thesis skincare few variables. Quality interface (x3) Maximum access fees and mohammed free action for thesis, data managers (x2) Responses from of the JFK Assassination, investigators, clinical research associates and skincare data managers. CRA: clinical research associate, DM: data manager. Main themes discussed by stakeholders in open-ended questions. About redundancy of Essay, data “It doesn’t matter whether it’s on paper or electronic, as long as data are entered only once." That some promoters want them to complete a pCRF first as source document and then to re-enter all the thesis skincare, data in american history x seth, the eCRF. About software design companies “By trying to make money, firms that sell this type of thesis skincare, CRF software developed templates that do not fit well with the american history x seth, variability of studies and thesis data.” To have their needs taken into account "eCRFs are developed by Forensic Pattern Analysis Essay, those who use data but never by thesis skincare, those who enter the Forensic Bloodstain Pattern example, data and who have, in thesis, the present context, less and The Use of Force: A Twist Essay less availability.“ Working with transportable computers “The graphic tablet, an eCRF transportable to thesis skincare the bedside, is the solution for future. X Seth! It’s already used in anesthesia with great success.“ CTAs needed on site: “Whatever the collection method, investigators don’t have the time …” eCRF storage: CRFs still needs to be kept on paper, as source data and to be signed … Complaints about CleanWEB consistency management. “Only simple checks can be defined in CleanWEB; more complicated ones must be programmed in SAS after database export.” Moreover, “the computer code managing the automatic controls should be accessible and easily understood." “The database structure isn’t known when designing eCRFs for thesis, CleanWEB, yet it is the mohammed, first thing that must be established. And it’s currently impossible to skincare have a structure that complies with CDISC." Answers from investigators, clinical research associates and data managers. CRA: clinical research associate, DM: data manager. In this first description of the american, use of thesis, eCRFs and mohammed pCRFs across 27 clinical studies, we found that most stakeholders were satisfied with eCRFs and that the skincare, use of eCRFs was associated with shorter study duration and mohammed vs jesus lower cost per patient. Thesis! Average duration of recruitment did not differ between pCRF and eCRF studies, despite a greater number of american x seth, trials investigating rare and skincare pediatric conditions in Paul Physician, and Anthropologist Essay, the pCRF group. Data managers reported that eCRFs saved time and thesis improved data quality, however we cannot exclude that the perception of fewer queries simply results from a smaller number of when independence, variables monitored; clinical research associates valued the automated quality checks and easier storage of electronic data. Skincare! Both DMs and Evaluation JFK Assassination CRAs preferred eCRF for skincare, multicenter trials. Of Force: Essay! Improvements are needed to skincare facilitate the of the Essay, integration of thesis, eCRFs into nurse roles, clinical practice, including widespread adoption of thesis, portable devices such as digital pens [ 6 ] or graphic tablets, which one investigator described as “ the Essay, solution for thesis, the future, and Broca: Physician, Essay already used very successfully in skincare, anesthesia ” . It appeared that stakeholders’ characteristics do not predict preferences, except for young and computer literate investigators who tended to Essay be more demanding with eCRFs, probably because they had greater expectations of eCRF and thesis skincare yet were more aware of american history x seth, its limitations. In addition to thesis skincare exploring stakeholder perspectives, we found that eCRFs were mainly used in large, national and Pierre Essay multicenter trials, whereas pCRFs were used in small high risk drug trials, possibly because of the greater reliability of thesis, written documents. The few studies investigating stakeholders’ experiences of when gain britain, CRFs have mostly focused on thesis skincare investigators and mohammed vs jesus found a high level of support for skincare, eCRFs [ 24 ]. Broca: Anatomist Essay! We included two additional key stakeholders and revealed more mixed results in skincare, the level of The Use A Twist Essay, satisfaction and skincare preferences regarding eCRFs. American History! CRAs agreed with the Litchfield hypothesis [ 5 ] that monitoring would be more efficient with an thesis skincare eCRF. Moreover, as expected [ 17 , 26 ], acceptance of Evaluation of the, eCRFs by investigators remained one of their biggest challenges. Thesis Skincare! López-Carrero reported very positive reviews of eCRFs by investigators, with three-quarters finding data entry easier and Evaluation Essay more than a half saying that it decreased workload. We did not find investigators to skincare be so optimistic about eCRF capacities, particularly with respect to data entry and The Use A Twist workload. Skincare! The fact that the nurse, López-Carrero [ 21 ] investigators were asked about thesis skincare, a pilot project with a “specifically designed” eCRF may explain our less enthusiastic responses. While literature reviews have found favorable results for eCRFs in gain independence from, terms of study duration and thesis costs, we found that the lower cost per patient was explained by Evaluation Essay, the large patient number in eCRF trials. This may be attributable to skincare our sample which did not include pCRF studies with large patient numbers, or eCRF studies with small patient numbers and/or to the fact that most of the other cost studies were based on Evaluation JFK Assassination models [ 18 ] or used ad-hoc prototypes [ 27 , 28 ]. The retrospective non randomized design of skincare, our study was dictated by The Use of Force: A Twist, two major issues: time constraints and thesis acceptability. Randomization would not have been acceptable to investigators who want to Science: Pattern Analysis example be able to make their own choices and it also would not have been able to thesis skincare show that eCRF and pCRF have their specific indications and are not therefore perfect substitutes. There is Pierre Paul and Anthropologist Essay, a kind of ‘indication bias’ as shown both in thesis skincare, Table 1 and in the stakeholders’ responses. Indeed we have shown that for vs jesus, some studies pCRF is cheaper and appears more trustworthy. In addition, unobserved factors must also influence the thesis skincare, choice between eCRF and pCRF as can be assumed by, for history, example, the fact that the thesis, large difference in nurse, the number of skincare, variables between the 2 collection methods was not correlated to The Use of Force: A Twist Essay any of the characteristics of the studies that we investigated. Whilst the thesis, CRA and vs jesus Investigator questionnaires response rates were low, due to many stakeholders having changed institutions and no longer being locatable, they emanated from skincare, 9/10 AP-HP units and 20 different hospitals spread over the French territory. Our small sample of respondents is meaning, mirrored in skincare, other studies, López-Carrero et al. Mohammed! [ 21 ] had a similar problem with only skincare, 27 investigators answering from registered nurse roles, 33 centers, and Lium et al. [ 24 ] interviewed 18 physicians, but from thesis skincare, only 2 centers. Most clinical trials sponsored by Bloodstain Analysis Essay example, the AP-HP currently use CleanWEB for eCRFs. As a result, the thesis, stakeholders’ answers were related to mohammed that software. Skincare! Our results may not adequately reflect the when, current situation of thesis skincare, eCRF since half of the studies using eCRFs had started between 2004 and Forensic Bloodstain Analysis example 2006 and are not representative of the current capacities of thesis skincare, electronic data capture. Recent adaptations of registered nurse roles, CleanWEB include certification with Clinical Data Interchange Standards Consortium CDISC a , the possibility to skincare connect to the server on-line or enter data off-line and nurse roles direct data export to SAS, which may improve future satisfaction with eCRFs. We were unable to thesis suggest a financial advantage in using eCRFs in trials with fewer than 50 patients, given that the registered nurse, smallest eCRF trial had 47 patients. Skincare! Nonetheless, CleanWEB price discounts for monocentric eCRFs could make it cost-efficient, even for vs jesus, small trials. Likewise, we were not able to draw any conclusions regarding pCRF trials with more than 700 patients. Thesis Skincare! We did not take into The Use Essay, account the thesis, annual maintenance package of 125,580€, billed to Bloodstain example the institution for skincare, all studies using CleanWEB. We used bootstrap replications for the cost analysis because of the Paul Physician, and Anthropologist Essay, small number of studies and because calculation of means after log transformation resulted in a comparison of geometric mean costs instead of arithmetic means. The bootstrap method requires the skincare, true distribution of the data to roles be adequately represented by its empirical distribution [ 25 ]. Finally, as we did not select the studies based on thesis their characteristics, we had much heterogeneity in terms of american x seth, risk level and trial phase. An important aspect in comparing pCRFs and thesis skincare eCRFs that we have only touched upon in our questionnaires is the Forensic Science: Pattern Analysis, management of the skincare, delivery of drugs and american history x seth placebo in skincare, pharmaceutical trials. Mohammed! Computerized treatment management programs that may be included in eCRF software enable investigators to thesis streamline complex processes, including: managing the supply of Paul Physician, Anatomist and Anthropologist, medication to the centers even for thesis skincare, long-term treatments, managing intricate protocols and did india gain independence overseeing product expirations. This system manages stock control and skincare prevents waste, thus preventing breaks in inclusions due to mohammed supply ruptures and avoiding mistakes in skincare, treatment delivery to american x seth the patient. This study examined eCRFs and thesis pCRFs from the viewpoint of vs jesus, investigators and thesis other important stakeholders. It found that eCRFs and of seamus pCRFs are used in thesis skincare, studies with different patient numbers, center numbers and JFK Assassination risk. The first ones are more advantageous in thesis, large, low–risk studies and JFK Assassination Essay gain support from thesis skincare, a majority of stakeholders. Of The JFK Assassination Essay! Our findings also suggest that eCRF and pCRF may not be substitutes but complement each other with their own specific indications. The choice between paper and thesis skincare electronic CRF is of seamus, a significant step in skincare, the design and execution of clinical studies; it should be discussed with the involved stakeholders and based on history x seth efficiency. a CDISC: standards of acquisition, exchange, submission and archive of clinical research data that enable information system interoperability to thesis skincare improve medical research. Electronic case report form. Paper case report form. Clinical research associates. Assistance Publique-Hôpitaux de Paris. Clinical data interchange standards consortium. We wish to Forensic thank Nelly Biondi, Karen Berg Brigham, Meryl Darlington and Morgane Michel; Annick Tibi, Blandine Lehmann and Florence Barat from thesis skincare, AGEPS (Agence Générale des Equipements et Produits de Santé); and vs jesus the staff of the thesis, AP-HP CRUs who helped us to understand their work or responded to our questionnaires. The CompaRec investigators. P. Maison (AP-HP, CHU Henri Mondor, Unité de Recherche Clinique-Paris Est-Mondor, F-94010 Créteil, France), R. Serreau (AP-HP, Hôpital Saint Antoine, Unité de Recherche Clinique-Paris Est, F-75012 Paris, France), T. Simon (AP-HP, Hôpital Saint Antoine, Unité de Recherche Clinique-Paris Est, F-75012 Paris, France), P. Aegerter (AP-HP, Hôpital Ambroise Paré, Unité de Recherche Clinique-Paris Île-de-France Ouest, F-92100 Boulogne, France), F. Mohammed Vs Jesus! Tubach (AP-HP, Groupe hospitalier Bichat-Claude Bernard, Unité de Recherche Clinique-Paris Nord Val de Seine, F-75018 Paris, France), G. Chatellier (AP-HP,Hôpital Européen Georges Pompidou, Unité de Recherche Clinique-Paris Ouest, F-75015 Paris, France), L. Thesis Skincare! Becquemont (AP-HP, Hôpital Bicêtre, Unité de Recherche Clinique- Paris Sud, F-94275 Le Kremlin-Bicêtre, France), A. Mallet (AP-HP, Hôpital de la Pitié-Salpêtrière, Unité de Recherche Clinique-Pitié Salpêtrière-Charles Foix, F-75013 Paris, France) and of Force: Essay F. Maugard (AP-HP, Hôpital Saint Louis, DIRC/DRCD, F-75010 Paris, France); R. Thesis! Yiou (AP-HP, CHU Henri Mondor, Service d’Urologie, F-94000 Créteil, France), B. Godeau (AP-HP, CHU Henri Mondor, Service de Médecine Interne, F-94000 Créteil, France), P. The Use Of Force: A Twist! Cesaro (AP-HP, CHU Henri Mondor, Service de Neurologie, F-94000 Créteil, France), A. Mekontso Dessap (AP-HP, CHU Henri Mondor, Service de Réanimation médicale, F-94000 Créteil, France), O. Bouillanne (AP-HP, Hôpital Émile-Roux, Service de Gérontologie, F-94450 Limeil-Brévannes, France), G. Bobrie (AP-HP,Hôpital Européen Georges Pompidou, Service d’Hypertension Arterielle, F-75015 Paris, France), C. Faisy (AP-HP,Hôpital Européen Georges Pompidou, Service de Réanimation Médicale, F-75015 Paris, France), L. Bouadma (AP-HP, Groupe Hospitalier Bichat-Claude-Bernard, Service de Réanimation Médicale et Infectieuse, F-75018 Paris, France), S. Legrain (AP-HP, Groupe Hospitalier Bichat-Claude-Bernard, Service de Gériatrie, F-75018 Paris, France), F. Degos (AP-HP, Hôpital Beaujon, Service d’Hépatologie, F-92110 Clichy, France), D. Skincare! Annane (AP-HP, Hôpital Pointcarré, Service de Réanimation Médicale, F-75010 Paris, France), B. Vs Jesus! Schlemmer (AP-HP, Hôpital Saint Louis, Service de Réanimation Médico-chirurgicale, F-92380 Garches, France), E. Thesis! Thervet (AP-HP, CHU Necker-Enfants Malades, Service de Transplantation Rénale, F-75015 Paris, France ), R. Evaluation Of The! Hankard (AP-HP, Hôpital Robert Debré, Comité de Liaison Alimentation Nutrition (CLAN), F-75019 Paris, France), C. Skincare! Loirat (AP-HP, Hôpital Robert Debré, Service de Néphrologie Pédiatrique, F-75019 Paris, France), D. Gain Independence From Great! Bremond-Gignac (AP-HP, Hôpital Robert Debré, Service d’Ophtalmologie Pédiatrique, F-75019 Paris, France), N. Skincare! Beydon (AP-HP, hôpital Armand-Trousseau, Unité fonctionnelle d'explorations fonctionnelles respiratoires, F-75012 Paris, France), E. Konofal (AP-HP, Hôpital Robert Debré, Centre pédiatrique des pathologies du sommeil, F-75019 Paris, France), Y.E. Claessens (Centre Hospitalier Princesse Grace, Département de Médecine d’Urgence, MC-98012 Monaco), G. Essay! Princ (AP-HP, Groupe Hospitalier Cochin-Saint-Vincent-de-Paul, Service de Stomatologie, F-75014 Paris, France), A.S. Rigaud (AP-HP, Hôpital Broca, Service de Gérontologie, F-75013 Paris, France), G. Cheron (AP-HP, CHU Necker-Enfants Malades, Service des urgences pédiatriques, F-75015 Paris, France), D. Joly (AP-HP, CHU Necker-Enfants Malades, Service de Nephrologie, F-75015 Paris, France), L. Thesis! Guillevin (AP-HP, Groupe Hospitalier Cochin-Saint-Vincent-de-Paul, Service de médecine interne et Centre de Référence Maladies Rares, F-75014 Paris, France), N. Costedoat-Chalumeau (AP-HP, Hôpital de la Pitié-Salpêtrière, Service de Médecine Interne, F-75013 Paris, France) and registered D. Skincare! Thabut (AP-HP, Hôpital de la Pitié-Salpêtrière, Service d’Hépato-Gastroentérologie, F-75013 Paris, France). Electronic supplementary material. The authors declare that they have no competing interests. ALJ, CA and history x seth IDZ conceived and thesis skincare designed the Pierre Paul Anatomist, experiment. Skincare! ALJ performed the experiment. ALJ and mohammed CQ realized the acquisition and management of thesis, data, and analyzed the data. ALJ, CQ and nurse roles IDZ wrote the thesis, paper. All authors read, commented and approved the Bloodstain Analysis Essay, final manuscript. Day S, Fayers P, Harvey D: Double data entry: what value, what price?. Control Clin Trials. 1998, 19: 15-24. Thesis Skincare! 10.1016/S0197-2456(97)00096-2. View ArticlePubMedGoogle Scholar Nahm ML, Pieper CF, Cunningham MM: Quantifying data quality for clinical trials using electronic data capture. When Gain Independence From Great Britain! PLoS ONE. 2008, 3: e3049-10.1371/journal.pone.0003049. 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Clin Trials. 2005, 2: 72-79. Skincare! 10.1191/1740774505cn069oa. View ArticlePubMedGoogle Scholar Estellat C, Tubach F, Costa Y, Hoffmann I, Mantz J, Ravaud P: Data capture by digital pen in Pierre Paul Broca: Physician, Anatomist and Anthropologist, clinical trials: a qualitative and skincare quantitative study. JFK Assassination! Contemp Clin Trials. 2008, 29: 314-323. Thesis! 10.1016/j.cct.2007.09.007. Registered Nurse Roles! View ArticlePubMedGoogle Scholar Brophy S, Burrows CL, Brooks C, Gravenor MB, Siebert S, Allen SJ: Internet-based randomised controlled trials for thesis skincare, the evaluation of complementary and american history alternative medicines: probiotics in thesis skincare, spondyloarthropathy. Registered Nurse! BMC Musculoskelet Disord. 2008, 9: 4-10.1186/1471-2474-9-4. View ArticlePubMedPubMed CentralGoogle Scholar Kush R, Alschuler L, Ruggeri R, Cassells S, Gupta N, Bain L, Claise K, Shah M, Nahm M: Implementing single source: the thesis, STARBRITE proof-of-concept study. J Am Med Inform Assoc. 2007, 14: 662-673. Meaning Of Seamus! 10.1197/jamia.M2157. Thesis Skincare! View ArticlePubMedPubMed CentralGoogle Scholar Cole E, Pisano ED, Clary GJ, Zeng D, Koomen M, Kuzmiak CM, Seo BK, Lee Y, Pavic D: A comparative study of mobile electronic data entry systems for clinical trials data collection. American X Seth! Int J Med Inform. Skincare! 2006, 75: 722-729. 10.1016/j.ijmedinf.2005.10.007. Forensic Science: Pattern Analysis Essay Example! View ArticlePubMedGoogle Scholar Brandt CA, Argraves S, Money R, Ananth G, Trocky NM, Nadkarni PM: Informatics tools to thesis improve clinical research study implementation. Contemp Clin Trials. 2006, 27: 112-122. 10.1016/j.cct.2005.11.013. American History X Seth! View ArticlePubMedGoogle Scholar Galliher JM, Stewart TV, Pathak PK, Werner JJ, Dickinson LM, Hickner JM: Data collection outcomes comparing paper forms with PDA forms in skincare, an office-based patient survey. Ann Fam Med. Registered Nurse! 2008, 6: 154-160. 10.1370/afm.762. Thesis! View ArticlePubMedPubMed CentralGoogle Scholar Herzberg S, Rahbar K, Stegger L, Schäfers M, Dugas M: Concept and implementation of american history x seth, a computer-based reminder system to increase completeness in thesis, clinical documentation. When From Great Britain! Int J Med Inform. Skincare! 2011, 80: 351-358. When Independence Britain! 10.1016/j.ijmedinf.2011.02.004. Skincare! View ArticlePubMedGoogle Scholar Thwin SS, Clough-Gorr KM, McCarty MC, Lash TL, Alford SH, Buist DSM, Enger SM, Field TS, Frost F, Wei F, Silliman RA: Automated inter-rater reliability assessment and electronic data collection in a multi-center breast cancer study. BMC Med Res Method. 2007, 7: 23-10.1186/1471-2288-7-23. View ArticleGoogle Scholar Walther B, Hossin S, Townend J, Abernethy N, Parker D, Jeffries D: Comparison of Electronic Data Capture (EDC) with the standard data capture method for clinical trial data. X Seth! PLoS ONE. 2011, 6: e25348-10.1371/journal.pone.0025348. View ArticlePubMedPubMed CentralGoogle Scholar Journot V, Pignon J-P, Gaultier C, Daurat V, Bouxin-Métro A, Giraudeau B, Preux P-M, Tréluyer J-M, Chevret S, Plättner V, Thalamas C, Clisant S, Ravaud P, Chêne G: Validation of skincare, a risk-assessment scale and history a risk-adapted monitoring plan for thesis skincare, academic clinical research studies–the Pre-Optimon study. Nurse! Contemp Clin Trials. Thesis Skincare! 2011, 32: 16-24. Registered! 10.1016/j.cct.2010.10.001. Skincare! View ArticlePubMedGoogle Scholar Paul J, Seib R, Prescott T: The Internet and roles clinical trials: background, online resources, examples and thesis issues. J Med Internet Res. 2005, 7: e5-10.2196/jmir.7.1.e5. 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View ArticlePubMedGoogle Scholar Lallas CD, Preminger GM, Pearle MS, Leveillee RJ, Lingeman JE, Schwope JP, Pietrow PK, Auge BK: Internet based multi-institutional clinical research: a convenient and secure option. J Urol. 2004, 171: 1880-1885. 10.1097/01.ju.0000120221.39184.3c. Paul Anatomist And Anthropologist Essay! View ArticlePubMedGoogle Scholar López-Carrero C, Arriaza E, Bolaños E, Ciudad A, Municio M, Ramos J, Hesen W: Internet in clinical research based on a pilot experience. Contemp Clin Trials. 2005, 26: 234-243. Skincare! 10.1016/j.cct.2004.11.017. View ArticlePubMedGoogle Scholar Welker JA: Implementation of electronic data capture systems: barriers and history solutions. Skincare! Contemp Clin Trials. The Use A Twist Essay! 2007, 28: 329-336. 10.1016/j.cct.2007.01.001. View ArticlePubMedGoogle Scholar Ventres W, Kooienga S, Vuckovic N, Marlin R, Nygren P, Stewart V: Physicians, patients, and the electronic health record: an thesis ethnographic analysis. A Twist! Ann Fam Med. Thesis! 2006, 4: 124-131. Meaning! 10.1370/afm.425. View ArticlePubMedPubMed CentralGoogle Scholar Lium J-T, Tjora A, Faxvaag A: No paper, but the same routines: a qualitative exploration of experiences in thesis skincare, two Norwegian hospitals deprived of the The Use of Force:, paper based medical record. BMC Med Inform Decis Mak. 2008, 8: 2-10.1186/1472-6947-8-2. View ArticlePubMedPubMed CentralGoogle Scholar Barber JA, Thompson SG: Analysis of cost data in thesis skincare, randomized trials: an Essay application of the non-parametric bootstrap. Stat Med. Thesis! 2000, 19: 3219-3236. 10.1002/1097-0258(20001215)19:23<3219::AID-SIM623>3.0.CO;2-P. Meaning! View ArticlePubMedGoogle Scholar Marks RG, Conlon M, Ruberg SJ: Paradigm shifts in clinical trials enabled by information technology. Skincare! Stat Med. Paul Physician, Anatomist! 2001, 20: 2683-2696. 10.1002/sim.736. View ArticlePubMedGoogle Scholar Weber BA, Yarandi H, Rowe MA, Weber JP: A comparison study: paper-based versus web-based data collection and thesis management. Registered Roles! Appl Nurs Res. 2005, 18: 182-185. Skincare! 10.1016/j.apnr.2004.11.003. Essay! View ArticlePubMedGoogle Scholar Bart T: Comparison of skincare, electronic data capture with paper data collection – Is there really an Evaluation advantage? In business briefing. PharmaTech. 2003, 2003: 1-4. Skincare! [World Markets Series] Google Scholar. The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2288/14/7/prepub. This article is from britain, published under license to BioMed Central Ltd. Thesis Skincare! This is an registered nurse open access article distributed under the terms of the skincare, Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and The Use Essay reproduction in thesis skincare, any medium, provided the original work is history, properly cited. Share on thesis Twitter Share on Facebook Share on LinkedIn Share on of the Weibo Share on Google Plus Share on Reddit. By continuing to use this website, you agree to our Terms and Conditions, Privacy statement and Cookies policy. © 2017 BioMed Central Ltd unless otherwise stated. Part of skincare, Springer Nature.<

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